Proxima A study

Future analyses of Proxima A are planned to continue to advance the understanding of the natural history of geographic atrophy

Proxima A study
Dermot McGrath
Dermot McGrath
Published: Thursday, September 14, 2017
An ongoing observational, prospective study of geographic atrophy (GA) patients should help to fill some important gaps in current understanding of the natural history of this advanced form of age-related macular degeneration, according to Jordi Mones MD, PhD, who presented his data at the 17th EURETINA Congress in Barcelona. “Previous natural history studies have provided valuable insight into GA but significant gaps remain with very limited long-term progression data and a real need for correlation of anatomic features with visual function outcomes,” he said. The Proxima A study, which is part of the lampalizumab study programme, seeks to address this shortfall by gathering data on almost 300 GA patients at up to 87 sites globally for duration of 48 months. Dr Mones said that the baseline visual function data demonstrated the presence of significant functional deficits highlighting the severity of geographic atrophy and its impact on patients’ quality of life. The mean baseline GA lesion size was 8.07 mm2 which is comparable with other observational studies. The baseline mean best-corrected visual acuity (BCVA) was 66.6 ETDRS letter and eyes with subfoveal involvement had lower BCVA by one line of vision. Dr Mones said that future analyses of Proxima A are planned to continue to advance the understanding of the natural history of geographic atrophy. Moreover, important year one data from the phase 3 lampalizumab clinical programme are expected before the end of 2017.
Latest Articles
Nutrition and the Eye: A Recipe for Success

A look at the evidence for tasty ways of lowering risks and improving ocular health.

Read more...

New Award to Encourage Research into Sustainable Practices

Read more...

Sharing a Vision for the Future

ESCRS leaders update Trieste conference on ESCRS initiatives.

Read more...

Extending Depth of Satisfaction

The ESCRS Eye Journal Club discuss a new study reviewing the causes and management of dissatisfaction after implantation of an EDOF IOL.

Read more...

Conventional Versus Laser-Assisted Cataract Surgery

Evidence favours conventional technique in most cases.

Read more...

AI Scribing and Telephone Management

Automating note-taking and call centres could boost practice efficiency.

Read more...

AI Analysis and the Cornea

A combination of better imaging and AI deep learning could significantly improve corneal imaging and diagnosis.

Read more...

Cooking a Feast for the Eyes

A cookbook to promote ocular health through thoughtful and traditional cuisine.

Read more...

Need to Know: Spherical Aberration

Part three of this series examines spherical aberration and its influence on higher-order aberrations.

Read more...

Generating AI’s Potential

How generative AI impacts medicine, society, and the environment.

Read more...