Novel keratoconus biomarker

Novel keratoconus biomarker
Dermot McGrath
Dermot McGrath
Published: Sunday, June 28, 2020
Jesper Hjortdal MD,PhD
Progress is being made on several fronts to advance understanding of the complex pathogenesis of keratoconus, including identification of a novel biomarker that may prove useful as a supplemental diagnostic test for the disease, according to Jesper Hjortdal MD, PhD. “Keratoconus remains an elusive disease where differentiation between association, cause, and effect is challenging and varies between individuals. Our research has identified a potential biomarker called Prolactin-Induced Protein (PIP), which seems to influence enzymes affecting corneal structure and homeostasis,” he said in a presentation at the World Ophthalmology 2020 Virtual Congress. Studies have shown that saliva, tears and serum samples reveal hormone imbalances in keratoconus patients, explained Prof. Hjortdal. “We are intrigued by the versatile function of PIP and the fact that it is regulated profoundly in keratoconus patients. The clinical significance of these observations is important and targeting PIP directly or indirectly may prove effective not only in early disease stages but also in advanced keratoconus stages,” he said. Using PIP as a biomarker for keratoconus and/or a therapeutic target would represent a significant paradigm shift in keratoconus research, added Prof. Hjortdal. He added that a lot of progress has also been made in epidemiological studies carried out in Denmark in recent years. “We know for instance that non-Europeans have more than threefold higher odds of keratoconus compared to Europeans, and that atopic dermatitis. allergic rhinitis and asthma are common among patients with keratoconus. The good news, however, is that keratoconus is not associated with higher mortality in Denmark,” he said.  
Tags: keratoconus biomarker
Latest Articles
ESCRS Today 2025: Happy Anniversaries!

ESCRS celebrates milestones with pioneers in IOLs, LASIK, femtosecond lasers, and corneal transplantation.

Read more...

ESCRS Today 2025: A Congress for Everyone

From YOs to families, the ESCRS Annual Meeting embraces full participation through inclusivity.

Read more...

ESCRS Today 2025: All Eyes on Innovation

Watching out for obstacles and opportunities

Read more...

Beyond the Numbers

Empowering patient participation fosters continuous innovation in cataract surgery.

Read more...

Thinking Beyond the Surgery Room

Practice management workshop focuses on financial operations and AI business applications.

Read more...

Aid Cuts Threaten Global Eye Care Progress

USAID closure leads retreat in development assistance.

Read more...

Supplement: ESCRS Clinical Trends Series: Presbyopia

Read more...

Debate: FS-LASIK or KLEx for Hyperopia?

FS-LASIK has more of a track record, but KLEx offers advantages.

Read more...

Four AI Applications Ready for Practice

Commercial offerings may save time, improve practice and research.

Read more...

Perioperative Medication Regimens for Cataract Surgery

Randomised controlled clinical trial results provide evidence-based guidance.

Read more...