NEUROTROPHIC KERATOPATHY AND TOPICAL INSULIN THERAPY - A CASE REPORT
Published 2025 - 29th ESCRS Winter Meeting
Reference: PO266 | Type: Free Paper | DOI: 10.82333/tz82-xp58
Authors: Fragkiskos - Stylianos Martinos* 1 , Chrysoula Sgourou 1 , Georgios Nikolaou 1 , Tina Xirou 1 , Anna Kouroupaki 1
1Opthalmology,General Hospital of Athens, Korgialeneio-Benakeio Hellenic Red Cross,Athens,Greece
Purpose
To present the clinical course of a patient with a resistant neurotrophic corneal ulcer that was treated with topical insulin drops, offering insights into a novel therapeutic approach.
Setting
Deparment of Opthalmology, Cornea Service, General Hospital of Athens, Korgialenio-Benakio Hellenic Red Cross, Athens, Greece
Methods
A 67-year-old female patient with a history of recurrent herpes simplex keratitis in the right eye (RE) developed a neurotrophic ulcer unresponsive to conventional therapeutic measures. As an alternative treatment, she received insulin drops three times daily. These drops were formulated by mixing lispro insulin in artificial tears containing dextran 70 0.1% and hypromellose 0.3%. Clinical follow-up assessments were conducted over two weeks.
Results
Within the two-week follow-up period, both the corneal ulcer and the clinical appearance showed marked improvement. This case demonstrates the potential effectiveness of topical insulin in healing resistant neurotrophic corneal ulcers.
Conclusion
Topical insulin therapy may offer a simple and effective treatment option for patients with resistant neurotrophic corneal ulcers. However, additional studies are warranted to confirm clinical efficacy and to evaluate the safety profile of insulin drops in ophthalmic applications.