ACUTE CALCAREOUS CORNEAL DEGENERATION IN A PATIENT WITH CHRONIC GRAFT-VERSUS- HOST DISEASE
Published 2025 - 29th ESCRS Winter Meeting
Reference: PO216 | Type: Presented Poster & Poster | DOI: 10.82333/wb36-x063
Authors: Marta Solaz Ruiz* 1 , Sergio Inat Moreno 1 , Ana Hervás Ontiveros 1
1Hospital La Fe,Valencia,Spain
Purpose
Description of acute calcareous corneal degeneration as a complication of chronic graft-versus-host disease.
Setting
We present a case of bilateral acute calcareous corneal degeneration in a patient with chronic graft-versus-host disease.
Methods
Clinical case report and revision of the actual literature.
Results
A 62-year-old woman diagnosed with angioimmunoblastic-type non-Hodgkin lymphoma underwent an allogeneic hematopoietic stem cell transplant and developed acute graft-versus-host disease with ocular complications including bilateral acute calcareous corneal degeneration. Despite the inmunosuppressive therapy and intensive lubrication, multiple therapeutic options were required, including amniotic membrane transplantation, keratoplasty, adhesive glues, and ultimately resulted in evisceration.
Conclusion
Chronic graft-versus-host disease (cGVHD) occurs in 50-70% of bone marrow transplantation patients, being keratoconjunctivitis sicca (KCS) the most frequent ocular complication. Calcareous corneal degeneration is a type of calcium deposition that can be secondary to chronic ocular inflammation or dry eye, but there are few cases reported of acute calcareous corneal degeneration and recurrent perforation in cGVHD.