THIS CASE SERIES EVALUATES THE TWO-YEAR RESULTS OF THE XENIA CORNEAL IMPLANT, A COMMERCIALLY AVAILABLE MEDICAL DEVICE DESIGNED FOR TREATING MODERATE TO ADVANCED KERATOCONUS AND POST LASIK ECTASIA

The commercially available corneal implant is a medical device designed for the treatment of moderate and advanced keratoconus. This case series describes a modified technique for using a commercially available device designed to overcome two limitations of the original technique

In this study, the implantation was performed on five eyes across five patients with advanced keratoconus. These patients had previously undergone corneal collagen cross-linking more than one year before. One patient underwent corneal cross-linking two weeks before the insertion of the inlay. The lenticules are extracted from porcine tissue, which is subjected to a decellularisation process, intensely cross linked, sterilised, and packed. is 44 +/-5 microns thickness and a diameter of 7.5 to 8.0mm. A modified technique was used to insert the device into a manually constructed pocket in the posterior corneal stroma.

In this study, the implantation was performed on five eyes across five patients with advanced keratoconus. These patients had previously undergone corneal collagen cross-linking more than one year before. One patient underwent corneal cross-linking two weeks before the insertion of the inlay. The lenticules are extracted from porcine tissue, which is subjected to a decellularisation process, intensely cross linked, sterilised, and packed. is 44 +/-5 microns thickness and a diameter of 7.5 to 8.0mm. A modified technique was used to insert the device into a manually constructed pocket in the posterior corneal stroma.

The modified technique of posterior corneal stromal implantation with pocket creation via manual delamination in combination with anterior corneal collagen cross-linking is safe and results in significant improvements in the following corneal parameters: Central corneal thickness increased from 429 +/-22.19 to 463 +/- 21.89, the maximum keratometry decreased from 63.4 +/-7.73 to 49.92 =/+2.37, and total higher-order aberrations decreased from 3.0778 +/-1.2 to 1.8924 +/-0.379, decreasing  Keratoconus staging from 3-4 to 1-2, and improving patient vision

This new novel technique for implants may become the standard surgical treatment for keratoconus that comprehensively addresses the disease and its visual consequences