EVALUATION OF SYSTEMIC INFLAMMATORY MARKERS IN PATIENTS WITH PSEUDOEXFOLIATION GLAUCOMA
Published 2025 - 29th ESCRS Winter Meeting
Reference: PO013 | Type: Presented Poster & Poster | DOI: 10.82333/06sx-dh96
Authors: Reyhan ATASOY* 1 , Busra KILIC 1 , Numan KUCUK 1 , Serdar BILICI 1 , Suat Hayri UGURBAS 1
1OPHTALMOLOGY CLINIC,ZONGULDAK BULENT ECEVIT UNIVERSITY FACULTY OF MEDICINE ,ZONGULDAK,Türkiye
Purpose
To evaluate the level of subclinical inflammation in cases of pseudoexfoliation glaucoma (PEG).
Setting
DEPARTMENT OF OPHTALMOLOGY, BULENT ECEVIT UNIVERSITY, ZONGULDAK, TURKEY
Methods
The medical records of 38 patients with pseudoexfoliation glaucoma (PEG) were retrospectively analyzed and matched by age and gender with 40 healthy controls. Levels of neutrophils, monocytes, lymphocytes, and platelets obtained from peripheral blood samples were recorded. As systemic inflammatory markers, the Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), Systemic Immune-Inflammation Index (SII - Platelet x NLR), and Systemic Inflammation Response Index (SIRI - Monocyte x NLR) were calculated and compared between the two groups.In case of a significant difference, ROC analysis was performed to determine the optimal cutoff values for NLR, PLR, SII, and SIRI in patients with PEG.
Results
Significant differences were found between the mean values of NLR (2.51 vs 1.58, p=0.01), SII (557.86 vs 196.23, p=0.01), and SIRI (1.49 vs 0.82, p<0.001) in PEG cases compared to healthy controls, while no significant difference was observed for PLR (130.33 vs 113.73, p=0.077). The area under the curve for NLR, SII, and SIRI in distinguishing PEG from controls was 0.637, 0.645, and 0.660, respectively, according to ROC analysis. The optimal cutoff values (with sensitivity and specificity) were 1.95 for NLR (%60.4 and %52.6), 498.03 for SII (%58.2 and %58.9), and 1.07 for SIRI (%62.6 and %64.6).
Conclusion
The presence of higher NLR, SII, and SIRI levels in PEG cases compared to healthy controls may indicate that subclinical systemic inflammation could be associated with the development of pseudoexfoliation. Further extensive studies should evaluate the relationship between systemic inflammation and the development and progression of PEG.