ESCRS - PO450 - Assessing Clinical & Molecular Outcomes Of Prophylactic Thermal Pulsation Therapy On Ocular Surface Health Post-Refractive Surgery

Assessing Clinical & Molecular Outcomes Of Prophylactic Thermal Pulsation Therapy On Ocular Surface Health Post-Refractive Surgery

Published 2022 - 40th Congress of the ESCRS

Reference: PO450 | Type: Free paper | DOI: 10.82333/hxpk-9j71

Authors: Ritica Mukherji* 1 , Rohit Shetty 2 , Arkasubhra Ghosh 3 , Swaminathan Sethu 3 , Pooja Khamar 1 , Sharon D'Souza 2

1Cataract and Refractive Services,Narayana Nethralaya,Bengaluru,India, 2Cornea and Refractive Services,Narayana Nethralaya,Bengaluru,India, 3GROW Labs,Narayana Nethralaya,Bengaluru,India

Purpose

To study ocular surface signs, symptoms, & tear film composition following prophylactic TPT(LipiFlow®) prior to refractive surgery. 

Setting

Narayana Nethralaya Super-speciality Eye Hospital, Bengaluru, India

Methods

Patients with/without mild-moderate evaporative dry eye disease or meibomian gland dysfunction undergoing refractive surgery were included. Group1 patients received TPT prior to LASIK (n=15;30 eyes) and Group 2 patients did not (n=15;30 eyes). Clinical parameters, Ocular Surface Disease Index (OSDI), Schirmer’s test (ST1,2), Tear film Break-Up Time (TBUT), meibography, tear film interferometry, & tear fluid was obtained 1 & 3 months post-operatively. Tear soluble factor profile measured by multiplex ELISA using flow cytometry.

Results

Improvement in post-surgical ST1, TBUT, OSDI observed in Group 1 subjects during the 3-month follow-up. The fold difference (3-month follow-up compared to basal) in tear inflammatory factors IL8, MCP1, CXCL10, NGAL &MMP9/TIMP1 ratio, also found to be lower in group 1. 

Conclusions

TPT (LipiFlow®) prior to refractive surgery improved post-surgical ocular surface signs, symptoms & reduced tear inflammatory factor profile, thus suggesting the plausibility of reduced post-operative complications like dry eye.