Gsto1, Gsto2, Gpx1 And Sod2 Polymorphisms Modify Susceptibility Of Developing Primary Open Angle Glaucoma
Published 2022
- 40th Congress of the ESCRS
Reference: PO422
| Type: ESCRS 2022 - Posters
| DOI:
10.82333/2rmx-kq84
Authors:
Miroslav Radivoje Stamenkovic* 1
, Aleksandra Popovic 1
, Biljana Vukadinovic 1
, Zoran Zikic 1
, Milos Plavsic 1
, Tatjana Djukic 2
, Sanja Radojevic 3
, Svetlana Sukalo 1
, Ana Savic-Radojevic 1
1Eye Clinic University Medical Center Zvezdara,Eye Clinic University Medical Center Zvezdara,Belgrade,Serbia, 2Institute of Biochemistry,Medical Faculty University of Belgrade,Belgrade,Serbia, 3Eye Clinic University Medical Center Zvezdara,Belgrade,Serbia
Purpose
A contributing role of disrupted redox homeostasis in pathophysiology and progression of primary open angle glaucoma (POAG) has been suggested. We aimed to assess the association between polymorphisms in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase (SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG.
Setting
Eye Clinic University Medical Center Zvezdara, Belgrade,
Methods
Single nucleotide polymorphisms of GSTO1 (rs4925), GSTO2 (rs156697), GSTP1(rs1695), as well as GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102 POAG patients and 302 respective controls.
Results
We found 8-fold increased risk for POAG development in carriers of both GSTO2*GG and GSTO1*AA variant genotypes (OR=8.21, p=0.002). Moreover, individuals who carried GPX1*TT and SOD2*CC genotypes had also an increased risk of POAG development (OR=6.66, p=0.005).
Conclusions
The present study supports the hypothesis that in combination, GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.
Keywords: primary open angle glaucoma, glutathione transferases, glutathione peroxidase, superoxide dismutase