ESCRS - PO382 - Corneal Endothelial Cell Loss After Preserflo Microshunt Implantation In The Anterior Chamber: Anterior Segment Oct Tube Location As A Risk Factor.

Corneal Endothelial Cell Loss After Preserflo Microshunt Implantation In The Anterior Chamber: Anterior Segment Oct Tube Location As A Risk Factor.

Published 2022 - 40th Congress of the ESCRS

Reference: PO382 | Type: Free paper | DOI: 10.82333/m3qp-9y89

Authors: Marta Ibarz Barberá* 1 , Laura Morales 2 , Fatima Martinez-Galdon 1 , Arturo Corroto 1 , Rosario Gomez de Liaño 2 , Pedro Taña 3 , Miguel Teus 4

1Glaucoma,Oftalvist Madrid,Madrid,Spain, 2Glaucoma,Hospital Clinico,Madrid,Spain, 3Glaucoma,Oftalvist Alicante,Alicante,Spain, 4Glaucoma,Hospital de Alcala de Henares,Madrid,Spain

Purpose

To analyze the effects of PRESERFLO on corneal endothelial cell density (ECD).

Setting

Glaucoma Unit of the HLA Moncloa Hospital, Oftalvist Group, Madrid, Spain. 

Methods

Forty-six eyes that underwent PRESERFLO implantation were followed-up for 12 months. Specular microscopy was performed preoperatively and at 1, 3, 6 and 12 months postoperatively to measure central ECD and mean monthly reduction (MMR). Anterior segment optical coherence tomography (AS-OCT) was applied to measure the tube-endothelium (TE < 200 mm, 201-500 mm, > 500 mm) distance. The relationship between TE distance and ECD was analyzed with a linear mixed-effects model.

Results

Central ECD decreased significantly at 1 year (7.4%, p=0.04), with an MMR of -15±25 cells/mm2. Regarding TE distance groups, there was an 18% ECD reduction in the < 200 mm group vs. 1% in the > 500 mm group (p=0.08). Endothelial cell loss was related to TE distance (mean 482.9 ± 238 mm), with a higher rate at 1 month in comparison to 12 months for the same tube position in the anterior chamber (-174.8±65.2 cells/mm2 at 1 month vs. 30.2±11.3 cells/mm2at 12 months, p<0.01). From month 6, tubes located > 600 mm from the endothelium showed EC loss close to zero.

Conclusions

The PRESERFLO implant is associated with a loss of EC from the immediate postoperative period that continues over time at lower rates. A shorter tube-endothelium distance appears to cause more severe ECD loss.