Lyell's Syndrome : Severe Even For The Eye? Two Cases Report

Published 2022 - 40th Congress of the ESCRS

Reference: PO363 | Type: ESCRS 2022 - Posters | DOI: 10.82333/fpvr-hy05

Authors: Reda Benchekroun* ¹ , hind hamdani ¹ , naoual mtalai ¹ , ghizlane daghouj ¹ , loubna elmaaloum ¹ , bouchra allali ¹ , asmaa Elkettani ¹

¹ophtalmologie pédiatrique,hôpital 20 Août 1953, CHU Ibn Rochd Casablanca,casablanca,Morocco

Purpose

Lyell's syndrome or toxic epidermolysis necrotising is a severe bullous dermatosis due to a hypersensitivity to a drug in the majority of cases. Ophthalmological manifestations are frequent in 50% of cases. Its severe ocular complications can alter visual function. We report the management and evolution of two cases with ocular Lyell syndrome

Setting

Pediatric ophtalmology, Hôpital 20 Août 1953, CHU Ibn Rochd Casablanca, Morocco

Methods

we report two cases of a 9-year-old and 14-year-old males hospitalized in the intensive care unit for lyell syndrome

Results

First case: severe mucocutaneous involvement. The ophthalmological examination found a central corneal ulcer, not perforated, multiple conjunctival serous cysts and a bilateral dry syndrome. The treatment was based on artificial tears, steroidal anti-inflammatories and antibiotic eye drops. The evolution was marked by a bilateral corneal opacification.

Second case: sequelae stage with severe dry syndrome, total bilateral corneal opacity, bilateral symblepharon at the lower and upper conjunctival fornix with the onset of entropion and trichiasic eyelashes. The patient was treated by resection of the conjunctival bands. The evolution was marked by recurrence of the symblepharon which led to surgery

Conclusions

Even early ophthalmological management doesn't always prevent severe ophthalmological sequelae. Toxic epidermal necrolysis remains a cause of blindness