Presumed Topical Minoxidil-Induced Unilateral Central Toxic Keratopathy Following Photorefractive Keratectomy
Published 2022 - 40th Congress of the ESCRS
Reference: PO055 | Type: Case report | DOI: 10.82333/n0g7-dc28
Authors: Mehrdad Mohammadpour 1 , Mohsen Heirani 1 , Masoud Khorrami-Nejad* 1 , Majid Moshirfar 2
1Tehran University of Medical Sciences,Tehran,Iran, Islamic Republic Of, 2Hoopes Vision Research Center, Hoopes Vision,Draper,United States
To report the clinical findings of unilateral central toxic keratopathy (CTK) associated with inadvertent exposure to topical Minoxidil 5% solution a day after bilateral photorefractive keratectomy (PRK).
A 27-year-old male who underwent bilateral PRK procedure was visited five days after surgery with complaint of acute decreased visual acuity in the left eye (LE). He was on treatment for post-hair transplant surgery with topical alcohol-based Minoxidil 5%. He reported that the topical Minoxidil 5% solution inadvertently was flowed into the LE on the first postoperative day. Clinical examinations five days after surgery, showed a manifest refraction of +6.00 / -5.00 x 45 in the LE. The uncorrected and corrected distance visual acuities of the LE were 20/200 and 20/25, respectively. On slit-lamp examination, a central corneal opacity was observed. In addition, irregularities in the epithelial map, central corneal thinning in the pachymetry map, and central flattening in the anterior segment optical coherence tomography image was found. The patient was monitored and after six months, uncorrected distance visual acuity and refraction of the LE were 20/20 and +0.50 D, respectively, and the cornea was clear.
It is recommended to warn patients who underwent refractive surgery concerning the alcohol-containing agents because of the possibility risk of CTK, a complication not formerly recognized.