ESCRS - PE028 - Repeated Sessions Of Photo-Activated Chromophore For Keratitis (Pack-Cxl) Window Absorption (Wa) For Treatment Of Resistant Bacterial Keratitis

Repeated Sessions Of Photo-Activated Chromophore For Keratitis (Pack-Cxl) Window Absorption (Wa) For Treatment Of Resistant Bacterial Keratitis

Published 2022 - 40th Congress of the ESCRS

Reference: PE028 | Type: ESONT - Abstract | DOI: 10.82333/3fkm-gz77

Authors: Mohammed Mohammed Mahdy Mohammed Mahdy Tawfeek* 1 , Ahmed M. Nashaat Ali Rady 2

1Ophthalmology department,Zagazig University - Faculty of Medicine,Zagazig,Egypt, 2Ophthalmology department,Merit University,Assiut,Egypt

Purpose

The aim of this work is to evaluate the safety and efficacy of repeated sessions of photo-activated chromophore for keratitis (PACK-CXL) window absorption (WA) for treatment of resistant bacterial keratitis.

Setting/Venue

Zagazig and Merit University hospitals - Ophthalmology departments.

Methods

This is a retrospective clinical cohort study. Thirty eyes with clinically suspected and lab confirmed bacterial keratitis which were resistant to appropriate antibiotic therapy  for 2 weeks with failure of epithelialization for 4 weeks after the standard anti-microbial therapy (SAT) together with one setting of PACK-CXL WA were included. These eyes underwent repeated sessions of PACK-CXL WA till start of epithelialization and complete corneal healing with scar formation  with negative culture on lab examination. Identification of organisms was done by lab study before and after treatment.

Results

Complete healing and resolution (Successful treatment) was observed in 25 eyes (83.33%) of cases and failure of epithelialization was observed in 5 eyes (16.67%). They were statistically significant (P =0.042 and 0.003) in comparison between both groups regarding success and failure of treatment, respectively. Complete corneal healing was reported in the second month postoperatively in 25 eyes (83.3 %) of cases. 

Conclusions

PACK-CXL WA is a promising, non-invasive treatment  for superficial bacterial keratitis.  Repeated sessions of PACK-CXL WA was found to be more beneficial for treatment of resistant bacterial keratitis till complete epithelialization and resolution of infectious keratitis than single session.