Comparison Of Effectiveness Between 50% Platelet-Rich Plasma (Prp) And 50% Autologous Serum Eye Drops In Dry Eye Disease.

Purpose: The objective of the study is to compare the efficacy of 50 % autologous serum eye drops with 50 % rich platelets plasma  eye drops in patients with moderate to severe dry eye disease.

Department of Ophthlamology,Prishtina

Republic of Kosovo

Methods: A total of 40 eyes were included in this prospective study. Clinical records of 20 consecutive patients with dry eye disease who had been treated with conventional 50 % autolog eye drops via topical (conventional treatment group) and 20 consecutive patients treated with 50 % topical PRP eye drops i(PRP eye drops treated group) and results were reported at 4 weeks. Topical platelet-rich plasma was prepared from total blood and enriched in platelets by centrifugation.

Results: Symptoms of dry eye, changes in corneal transparency and other changes were significantly improved in the plasma group compared to conventional serum group . The SCHIRMER test increased by several points. Primary outcomes are fluorescein break-up time, Schirmer’s I test, and TBUT. Other measured outcomes include best-corrected visual acuity, intraocular pressure and compliance. No complications were observed during short term follow-up.

Conclussion: It can be concluded from these studies that the therapeutic response with topical

drops of PRP was actually satisfactory in severe or moderate  dry eye cases which comparing to

 conventional therapy with autologous serum. The topical use of autologous platelet-rich plasma

as monotherapy is an effective treatment to improve signs and symptoms in patients suffering

from moderate to severe chronic DED.