The Save Sight Dry Eye Registry: One Year Capture Of Real-World Data For Dry Eye

Published 2022 - 40th Congress of the ESCRS

Reference: FPS11.08 | Type: Free paper | DOI: 10.82333/wwvc-ht88

Authors: Stephanie L Watson* ¹ , Maria Cabrera Aguas ¹ , Fiona Stapleton ² , Saaeha Rauz ³ , David Mingo Botin ⁴ , Francisco Arnalich ⁴ , Laura Downie ⁵ , Vincent Daien ⁶ , Fanny Babeau ⁶ , Jennifer Craig ⁷ , Himal Kandel ¹ , Alberto Recchioni ³ , Gerd Geerling ⁸

¹Ophthalmology,Save Sight Institute, The University of Sydney,Sydney,Australia, ²University of New South Wales,Sydney,Australia, ³Academic Unit of Ophthalmology,Institute of Inflammation and Aging,Birmingham,United Kingdom, ⁴Ophthalmology,Hospital Universitario Ramon y Cajal,Madrid,Spain, ⁵Optometry,University of Melbourne,Melbourne,Australia, ⁶Ophthalmology,Centre Hospitalier Universitaire (CHU) Montpellier,Montpellier,France, ⁷Ophthalmology,University of Auckland,Auckland,New Zealand, ⁸Ophthalmology,University Hospital Duesseldorf,Duesseldorf,Germany

Purpose

The Save Sight Dry Eye Registry (SSDER) is the first international web-based multinational, interdisciplinary registry able to collect high-quality outcome data from patients in clinical settings. We report the characteristics of patients with dry eye disease (DED) at their baseline visit from routine clinical practice from 1 November 2020 to 11th March 2022.

Setting

Academic and private ophthalmology and optometry practices in Australia and Europe

Methods

The SSDER collected data from routine clinical practice in Australia, Spain, Germany, and the United Kingdom. Patient demographics, medical history and index visit characteristics, such as visual acuity (VA), tear break up time (TBUT), ocular surface staining and ocular surface staining score were recorded in the prospectively designed electronic database. Ocular surface disease index (OSDI) questionnaire was also completed. Primary outcomes were the baseline demographic data and dry eye diagnosis and secondary outcomes; VA in logMAR letters, TBUT, and ocular surface staining score, and the OSDI score. 34 clinicians from 30 practices were registered to use the registry. 34 clinicians from 30 practices were registered to use the registry.

Results

Data from 344 eyes from 173 patients with mean(SD) age 58.1 (5.7) years (range 18-93) and 82.7% (n=143 patients) were female were included.

39.8% (n =137) of eyes had mixed DED 49.7% (n = 171), evaporative DED, 8.1% (n = 28) aqueous deficient DE, and 2.3% (n = 8) corneal neuropathic pain. Ten (5.8%) patients wore CLs. Most eyes (n = 240, 69.8%) had Meibomian gland disease.

The median visual acuity and TBUT at baseline were 83 (IQR 75-85) logMAR letters and 4 (IQR 2-8) sec, respectively.

Ocular surface staining was graded as none (n = 101, 29.4%), minimal (n= 107, 31.1%), mild (n = 73, 21.2%), moderate (n = 48, 14.0%) and severe (n = 15, 4.4%).

71% of patients completed the OSDI, the mean score was 34 (SD,23)

Conclusions

The SSDER allows the efficient capture of dry eye patient data from everyday clinical practice. Meibomian gland disease was present in most patients with dry eye from real world settings.