Dysfunctional Tear Syndrome On The Background Of Covid-19
Published 2022
- 40th Congress of the ESCRS
Reference: FPS11.07
| Type: Free paper
| DOI:
10.82333/dgj7-yq75
Authors:
Dilbar Kamaldjanovna Makhkamova* 1
, Munirakhon Kasimova 2
, Mufazzal Iminova 2
1Pathology of Optic Nerve and Retina,Republican Specialized Scientific-practical Medical Center of Eye Microsurgery,Tashkent,Uzbekistan, 2Ophthalmology,The Center of the development of professional qualification of medical workers,Tashkent,Uzbekistan
Purpose
To study the tear production of the organ of vision in patients suffering from COVID-19 at the height of the disease, taking into account inflammation markers in the lacrimal fluid
Setting
The results of clinical and functional studies were based on the analysis of data from 112 patients hospitalized in a specialized multidisciplinary clinic for the treatment of coronavirus patients with a confirmed diagnosis of COVID-19 during the manifestation of the disease. The criterion for inclusion in the study was the presence of COVID-19 during the manifestation period on the 5th day from the onset of the first symptoms, with severe and moderate course, without ophthalmic pathology.
Methods
The patients were divided into 2 groups depending on the severity of the course of the underlying disease and the control group. In the 1st group-56 patients with a severe course, the 2nd group - 56 patients with a moderate course of the disease, the control group - 20 healthy individuals. Research methods visiometry, tonometry, determination of tear production using the Schirmer-1 and Schirmer-2, biomicroscopy, ophthalmoscopy, analysis of lacrimal fluid for the presence of inflammatory mediators such as: IL-6, TNF-α. The content of cytokines IL-6, TNF-α in the lacrimal fluid was determined by enzyme immunoassay on the first day of admission to the hospital, as well as 1 month after discharge using the test system on the ASCENT analyzer
Results
If the 1st group, it was found that there is an inhibition of tear production in all patients. The Schirmer test 1 averaged 6±1.5 mm* and the Schirmer test 2 was 5±1.5 mm* (maximum reduction 1 mm).
The parameters of the Schirmer 1 test in the 2nd group were 7 ± 2.0 mm* (maximum reduction up to 3 mm) and Schirmer 2 5 ± 2.0 mm* (maximum reduction up to 3 mm).
* - (p˂0.05) according to the t criterion in relation to the 2nd group with a moderate course. A significant correlation was also found between the levels of cytokines in the lacrimal fluid and Schirmer's test.
The level of cytokines in the lacrimal fluid was: severe IL6-8.57±0.49 pg/ml*, TNF-α-7.26±0.52 pg/ml*; moderate degree IL6-4.73±0.5 pg/ml *,
TNF-α-3.72±0.16 pg/ml*
Conclusions
The decrease in the volume of tear production observed at the height of the disease in patients with severe and moderate course of COVID-19 correlates with the level of pro-inflammatory cytokines, which allows us to consider it (the volume of tear production) as a criterion for the severity of the inflammatory reaction occurring in the tissues of the organ of vision