ESCRS - FPS03.10 - What Is The Relationship Between Oxybuprocaine And Cornea - Does Its Thickness Stand In Their Way?

What Is The Relationship Between Oxybuprocaine And Cornea - Does Its Thickness Stand In Their Way?

Published 2022 - 40th Congress of the ESCRS

Reference: FPS03.10 | Type: Free paper | DOI: 10.82333/w0zw-8a98

Authors: Ines Matoc* 1 , Aida Kasumović 2 , Idoia Goni Guarro 2 , Valentina Lacmanović Lončar 2 , Ivanka Petric Vicković 2 , Zoran Vatavuk 2

1Ophthalmology,KBC Sestre milosrdnice Zagreb,Zagreb,Croatia;Ophthalmology,KBC Sestre milosrdnice Zagreb,Zagreb,Croatia, 2Ophthalmology,KBC Sestre milosrdnice Zagreb,Zagreb,Croatia

Purpose

To determine the effect of oxybuprocaine on epithelial and corneal thickness in healthy subjects obtained by anterior segment OCT.

Setting

 
This prospective study was conducted at University Department of Ophthalmology,
University Hospital Center „Sestre milosrdnice“ Zagreb, Croatia, between December 2021 and March
2022.

 

Methods

The cornea was imaged by optical coherence tomography for the anterior segment (AS OCT, AngioVue, Avanti RTVue-XR, Optovue, CA) in this prospective study. Measurements were performed on 50 eyes of 25 subjects before and consecutively every minute, for five minutes, after instilling a drop of 0.4% oxybuprocaine in one and saline solution in the other eye (control group) and two additional measurements after instilling the second drop. In the central 7-mm corneal zone the following parameters were compared: superior and inferior corneal epithelial thickness, thickest and thinnest epithelial point, epithelial thickness variability and central corneal thickness. The effect of tear film was reduced by blinking prior to each scan.

Results

CCT, superior, inferior, minimum and maximum epithelial thickness underwent similar changes after anaesthetic or saline solution instillation. Small but statistically insignificant (P>0.05) increase in values ​​after the first drop was shown, followed by a gradual return to the original values ​​with some oscillations and remained stable for 5 minutes after the second drop. The greatest changes were observed 30 seconds after the first drop of anesthetic. The difference between the initial values ​​for the parameters: CCT, superior and inferior thickness of the corneal epithelium, the thinnest and thickest point of the epithelium and those 30 seconds after instillation of anesthetics ranged in order: 1-6µm, 1-9µm, 0-4µm, 0 to 10µm, 0 to 9µm.

Conclusions

Instilling one or two drops of local anesthetic 0.4% oxybuprocaine leads to a mild and short-term but statistically insignificant increase in epithelial thickness and central corneal thickness at all corneal sites, evaluated by AS OCT. The effect of the local anesthetic should be considered during intraocular pressure measurements and preoperative measurements for laser in situ keratomileusis.