Role Of Steroid Sparing Topical Agents In Preventing Recurrence Of Sub-Epithelial Infiltrates Following Adenoviral Keratoconjunctivitis: Topical Cyclosporin A 2% Versus Tacrolimus Ointment 0.15%.

Published 2022 - 40th Congress of the ESCRS

Reference: FPM06.03 | Type: Free paper | DOI: 10.82333/p96r-n017

Authors: Amit Gupta* ¹ , Barkha Gupta ² , Sraddha Limbu ² , Mayur Jain ² , Arun K Jain ² , Chintan Malhotra ² , Sonam Yangzes ²

¹Advanced Eye Centre,PGIMER,Chandigarh,India;Advanced Eye Centre,PGIMER,Chandigarh,India, ²Advanced Eye Centre,PGIMER,Chandigarh,India

Purpose

To study the efficacy of topical Cyclosporin A (CsA) 2% versus Tacrolimus ointment0.15% in treating sub-epithelial infiltrates (SEI) following adenoviral keratoconjunctivitis (AKC).

Setting

Cornea Clinic

Advanced Eye Centre,

Postgraduate Institute of Medical Education and Research,

Chandigarh,

India

Methods

40 eyes with active SEI post-AKC were randomized into: Group I- 20 eyes on CsA 2 % (CsA 0.05% in intolerant patients) eye drops, Group II-20 eyes on Tacrolimus (0.15% eye ointment) twice daily, for 3 months. Topical Betamethasone 0.1% was given for initial 3 weeks. Visual, subjective and objective parameters were compared. Topical loteprednol 0.2% was added in case of recurrence.

Results

Comparing CsA 2 % versus Tacrolimus 0.15%, final BCVA was 0.025 versus 0.015, p=0.695, OSDI score 15.4 versus 20.42, p=0.157, decrease in SEI score by 2.05 versus 3.80, p=0.014 at 3 months respectively. 70% patients were intolerant to CsA 2%. Recurrence was seen in 17 eyes (85%) in CsA versus 9 eyes (45%) in tacrolimus group.

Conclusions

We found that steroid sparing immunomodulators were ineffective in treating and decreasing the recurrences of sub-epithelial infiltrates.