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Predicted long-term graft survival after Descemet membrane endothelial keratoplasty (DMEK)

Session Details

Session Title: Cornea

Session Date/Time: Sunday 17/02/2013 | 08:30-11:00

Paper Time: 10:22

Venue: Hall 2

First Author: : L.Baydoun THE NETHERLANDS

Co Author(s): :    V. Borderie   I. Dapena   L. Ham   G. Melles     

Abstract Details


To predict the long term (10-year) graft survival rate after Descemet membrane endothelial keratoplasty (DMEK), using a simulation model.


Non randomized, retrospective analysis of prospectively collected data at a tertiary referral center. Netherlands Institute for Innovative Ocular Surgery, Rotterdam


223 consecutive eyes of 223 patients who underwent DMEK for Fuchs endothelial dystrophy (FED, n=200) and bullous keratopathy (BK, n=16) or as a secondary endothelial keratoplasty (SEK, n=7) for low visual outcome or graft failure after Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK). A simulation model was used to predict 10-year graft survival rate, using the following parameters: actual graft survival and pre- and postoperative donor endothelial cell densities (ECD).


The actual observed 3-year and predicted 10-year graft survival rates favourably compared to penetrating keratoplasty, but differed significantly between the three subgroups (FED vs BK and FED vs SEK). Graft survival rates (observed and predicted) were highest in eyes operated on for FED compared to eyes with BK or SEK.


DMEK may show promising 10-year graft survival rates, especially in eyes operated on for FED. Lower predicted survival rates after BK or SEK are based on small subgroups and may in part be explained by concomitant ocular pathology in these eyes.

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