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Reproducibility of MP3 microperimetry in open-angle glaucoma patients

Poster Details

First Author: S.Georgiev AUSTRIA

Co Author(s):    S. Palkovits   C. Leisser   N. Hirnschall   O. Findl           

Abstract Details

Purpose:

Primary open-angle glaucoma is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of that disease, functional tests, such as standard automated perimetry, are the main diagnostic tool to detect progression. Compared to standard automated perimetry, microperimetry offers fundus imaging with motion tracking to ensure precise stimulation of certain locations of the retina. Aim of our study was to assess repeatability of measurements with MP3 microperimetry device in patients with POWG and compare results to standard automated perimetry.

Setting:

Hanusch Hospital, Department of Ophthalmology

Methods:

This prospective monocenter study included patients suffering from POWG with visual field defects in the central 20┬░ zone. After inclusion into the study, three consecutive study visits were scheduled within one month, assessing microperimetry and standard automated perimetry at each visit.

Results:

From 19 patients recruited, data from 18 patients could be analyzed. No significant difference between study visits could be detected in mean retinal sensitivity in microperimetry and SAP (MP3: p=0.401, SAP: p=0.644; Friedman┬┤s 2-way ANOVA). The intraclass-correlation coefficient (ICC) was 0.981 (CI: 0.978 to 0.984) for microperimetry and 0.948 (CI: 0.941 to 0.955) for SAP. Absolute agreement between deep scotoma points was found in 81 test locations (79%) in microperimetry and in 35 test locations (20%) in SAP (p=0.003, chi-square test).

Conclusions:

Microperimetry and conventional perimetry showed high reproducibility, with slightly better performance of the former. Microperimetry is a promising technique in evaluation visual fields and its progression in glaucoma patients. However, the reduced angle of visual field in microperimetry limits its application to central glaucomatous field damage. Introduction of an increased angle of visual fields and implementation of a normative database for microperimetry would enable diagnosis of glaucomatous field defects according to actual standards.

Financial Disclosure:

None

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