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Spontaneous corneal perforation and lens protrusion in a premature infant with Peters Syndrome

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Session Details

Session Title: Presented Poster Session: Infections & Syndromes

Venue: Poster Village: Pod 3

First Author: : E.Alyamaç Sukgen TURKEY

Co Author(s): :    Y. Kocluk                       

Abstract Details


A male premature infant born at a gestational age of 28  weeks with a birth weight of 1050 gram was reffered to our clinic to screening of retinopathy of prematurity (ROP) at the postmenstruel age of 32 weeks. At the initial examination, the infant’s right cornea had a central defect of all corneal layers with lenticular protrusion. Purpose of the study is to present results of amniotic membrane transplantation and intravitreal Aflibercept injection for the treatment of spontaneous corneal perforation in Peter’s Syndrome and prophylactic treatment of ROP.


Retrospectively, medical records of the case were analyzed in Adana Numune Training and Research Hospital.


Fundus examinations of both eyes could not be performed. B-scan ultrasound was performed to evaluate fundus finding in the left eye, not right eye. Also, in the left eye was observed a central corneal opacity, corneal thinning, and an iridocorneal adhesion. Then emergent surgical treatment was made under general anesthesia for the right eye. Lens extraction and anterior vitrectomy were performed and then three-fold amniotic membrane transplantation was made to cover the corneal defect. 1 mg/ 0.025 mL Aflibercept was applied for prophylactic purpose to prevent sequel of ROP. The left eye was followed up.


The patient followed-up at the first day, first week, first month and third month post-operatively.In the early period there was an amniotic membrane on the eye and ocular evaluation couldn’t be made. But, three months after the surgery, the right eye of patient was successfully preserved. There were central corneal opacity with normal B-scan ultrasounographic findings in the right eye. But, there were total corneal opacity with pre-phthitic appearence in the left eye and retinal detachment was also observed on B scan ultrasound.


To our knowledge, spontaneous corneal perforation in the perinatal period is rare, and only a few cases are described in the literatüre. Also, a case with spontaneous corneal perforation along with lens protrusion has not been published yet. On the other hand, ROP is the big problem for the premature infants. To preserve the eye was performed penetran keratoplasty or conjunctival flap tecnique. In this case, favorable anatomic results were obtained three-fold amniotic membran covering and prophylactic intravitral aflibercept treatment.

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