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Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


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Causes of congenital corneal opacities and their management in a tertiary care center

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Session Details

Session Title: Presented Poster Session: Cornea: Medical

Venue: Poster Village: Pod 2

First Author: : R.Karadag TURKEY

Co Author(s): :    C. Rapuano   K. Hammersmith   P. Nagra                 

Abstract Details


To evaluate causes and management of congenital corneal opacities (CCO) seen in a tertiary care eye center.


Retrospective review of the computerized medical records of all patients with congenital corneal opacities seen on the Cornea Service at Wills Eye Hospital (Philadelphia, PA) between January 1, 2007, and December 31, 2015.


Children who were 12 years old and younger at the first visit at Wills were included in the study. Patients’ demographics, ocular diagnosis, laterality, associated ocular abnormalities, other ocular surgery that was performed prior or subsequent to first visit, and the treatment were extracted from medical records.


Seventy-seven eyes of 56 patients were included in the study. The mean presenting age was 32.844.2 months, the mean follow-up period was 26.730.1 months. The most frequent diagnosis was Peters anomaly (53.2%), followed by limbal dermoid (13.0%), aniridia with glaucoma (6.5%), microphthalmos (6.5%), sclerocornea (5.2%), congenital glaucoma (5.2%) idiopathic corneal opacity (3.9%), Axenfeld-Rieger anomaly (2.6%), Hurler syndrome (2.6%), and microcornea (1.3%). Twenty-six eyes underwent primary keratoplasty. Five eyes underwent a second keratoplasty. Two eyes underwent a third keratoplasty and one eye a fourth keratoplasty.


Peters anomaly is the most common cause of CCO at our institution. Penetrating keratoplasty is the most frequent choice of corneal surgery to treat CCOs. About three quarters of keratoplasty surgery cases were patients with Peters anomaly. Additional interventions during keratoplasty had a moderate positive correlation with graft failure. Moreover, this study shows rates of some etiologies of CCO have changed over the recent decades on our tertiary care Cornea Service. CCO due to birth trauma, which is one of the preventable causes, was seen in our clinic’s previous study but no new case was seen in this study.

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