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Cross-linking for post-LASIK corneal ectasia: flap-on 3-minute and flap-off 30-minute protocol

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Session Details

Session Title: Presented Poster Session: Cross-Linking

Venue: Poster Village: Pod 2

First Author: : S.Chen CHINA

Co Author(s): :                           

Abstract Details


To evaluate the outcomes of corneal collagen crosslinking (CXL) for management of corneal ectasia after LASIK.


Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China


CXL was performed in 15 eyes of 13 patients either with LASIK flap lift (n=8; 365-nm, 30-mW/cm2, 3 minutes) or with epithelium-on flap-on (n=7 eyes; 365-nm, 3- mW/cm2, 30 minutes) technique. Postoperative change in maximum keratometry (Kmax), spherical equivalent (SE), logMAR uncorrected distance visual acuity (UDVA), and central corneal thickness (CCT) were evaluated.


There was a significant improvement in SE at 3 (-7.83 vs -6.38; p=0.029) and 12 months (- 7.83 vs -6.13; p=0.036) postoperatively. The Kmax values decreased from 57.2 diopters preoperatively to 55.4 diopters by 3 months and 55 diopters by 12 months postoperatively. The median UDVA changed from 0.82 preoperatively to 0.91 at 3 months postoperatively (p=0.166). The initial improvement in spherical equivalent was more pronounced after flap-off CXL as compared to flap-on CXL (p>0.05). The Kmax flattened more after flap-off CXL whereas there was a slight increase in Kmax after flap-on CXL (p>0.05)


In our study, collagen crosslinking was successfully used to halt disease progression in post-LASIK keratectasia. We recommend flap-on surgical technique for these cases.

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