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Long-term clinical course of LASIK/LASEK combined with collagen cross-linking

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Session Details

Session Title: Surgical Cornea

Session Date/Time: Tuesday 25/09/2018 | 16:30-18:00

Paper Time: 17:18

Venue: Room A3, Podium 3

First Author: : K.Shin SOUTH KOREA

Co Author(s): :    S. Choi   J. Kim   D. Paik   K. Shin   T. Chung   D. Lim     

Abstract Details


It has been reported that the rate of complications such as keratoconus increases with decreasing thickness of the remainder cornea following photorefractive surgeries such as laser-assisted in situ keratomilieusis (LASIK) or photorefractive keratectomy (PRK). In order to overcome such devastating post-surgical complications, corneal cross-linking has been introduced to enhance corneal resilience after photorefractive surgery in highly myopic eyes. In this study, we investigated the long-term clinical course of LASIK and LASEK surgery when combined with corneal collagen cross-linking in high myopia patients.


Samsung Medical Center, Sung Kyun Kwan University School of Medicine


This is a retrospective study in which, from April, 2014 to May, 2015, a total of 246 subject, 481 eyes, underwent either LASIK or PRK combined with corneal cross-linking (LASIK-XTRA® or LASEK-XTRA®, respectively). The postoperative changes in visual acuity, refraction, high-order aberrations, corneal endothelial cell count and corneal opacity were observed at 1, 3, 6 months after the surgery.


LASIK-XTRA® and LASEK-XTRA® groups both showed significantly enhanced visual acuity and refraction in all follow-up periods after surgery. There was no statistical difference in preoperative and postoperative visual acuity and refraction between the two groups. A significant postoperative increase in corneal opacity was observed in both groups. In 5 eyes, corneal opacity manifested in clinical symptoms, such as decreased visual acuity and increased aberrations, showing statistical correlations with corneal flattening with hyperopic changes.


In conclusion, LASIK and PRK showed acceptable results suggesting photorefractive surgeries are safe and efficacious when combined with corneal cross-linking. However, the rate of postoperative corneal opacity including hyperopic changes is not low and cautious approach for further investigation is required.

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