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Vienna 2018 Delegate Registration Programme Exhibition Virtual Exhibition Satellites 2018 Survey


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Sleep outcomes in patients with dry eye disease

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Session Details

Session Title: Medical Cornea & Biomechanics

Session Date/Time: Sunday 23/09/2018 | 08:00-10:00

Paper Time: 08:24

Venue: Room A3, Podium 3

First Author: : R. Mather CANADA

Co Author(s): :    M. Malvankar-Mehta   N. Au   A. To              

Abstract Details


To summarize and quantitatively evaluate sleep outcomes of Dry Eye Disease (DED) patients.


Western University, Ivey Eye Institute, London, Ontario, Canada


A systematic review and meta-analysis. PARTICIPANTS: DED patients included individuals with dry eye symptoms or primary Sjogren’s Syndrome (pSS). Controls were healthy, non-pSS or non-DED patients.


A systematic search of MEDLINE, EMBASE, PsycINFO and grey literature was conducted. Studies were screened using Covidence systematic review software. Outcomes included: sleep quality, duration, daytime sleepiness, prevalence/incidence/severity of sleep disorders, and sleep disturbances. Meta-analysis was conducted using STATA 13.0. The weighted mean difference (WMD) was calculated as the effect size for continuous scale outcomes. Random effects models were developed based on the presence of heterogeneity.


Seventeen full-text articles (16,370 subjects) and three conference abstracts (572,163 subjects) were included. Compared to controls, DED patients score higher on the Pittsburgh Sleep Quality Index (WMD = 1.69, 95% CI: [0.82, 2.56]; 2=88.8%, p<0.001) and Epworth Sleepiness Scale (WMD = 2.26, 95% CI: [0.96, 3.56]; I2 = 82.4%, p<0.001). Additionally, DED patients spend less time asleep (WMD = -0.59 hours, 95% CI: [-0.94, -0.24]; I2 = 85.1%, p<0.001), experience more sleep disturbances, and may have increased prevalence, incidence, severity of sleep disorders.


CONCLUSION: DED patients may have poorer sleep quality, greater daytime sleepiness, less sleep, more sleep disturbances, increased prevalence, incidence, and severity of sleep disorders compared to non-DED patients. Further research is needed to identify potential causes of these outcomes given the paucity and heterogeneity of studies. It may be worthwhile to consider sleep in the clinical management of DED.

Financial Disclosure:


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