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Two-year results of allogenic corneal lenticule of hyperopic SMILE for post-LASIK ectasia

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First Author: M.Li CHINA

Co Author(s):    X. Zhou                    

Abstract Details


To investigate the safety, efficacy, and corneal changes following allogeneic lenticule implantation for post-LASIK corneal ectasia.


Department of Ophthalmology, EYE & ENT Hospital of Fudan University, Shanghai, China


In this prospective, interventional case series, seven eyes from seven patients (five males, two females) with post-LASIK ectasia presenting during the period between 2015 and 2018 were included in this study. For the recipient eyes, flaps were opened and lifted. Lenticules with a mean cryopreserved time of 20±21 days extracted from the SMILE donor were transferred on to the exposed stromal bed and the flap was repositioned.Patients were followed up for a period of 2 years. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, manifest refraction, corneal topography, optical coherence tomography (OCT), and in vivo confocal microscopy were performed.


On the last visit, the safety and efficacy indices were 1.49±0.39 and 0.74±0.59, respectively. UDVA improved from 1.59±0.41 preoperatively to 0.79±0.35 (LogMAR). Two eyes (29%) gained one line of CDVA, three (43%) gained two lines, and one (14%) gained three lines. No eyes lost more than two lines. Spherical equivalents decreased from -11.95±5.91 D to -7.46±4.79 D (P=0.029). Anterior K of six eyes (85.7%) decreased greater than 1.0 D. Mean anterior K values changed from 53.91±7.80D to 51.11±8.51D (P=0.005). The smallest corneal thickness increased from 353.1±48.7μm to 405.1±56.5 μm(P=0.0008).


Results of this study indicate that implantation of a concave allogenic lenticule may provide an alternative in the treatment of post-LASIK ectasia, although its refractive predictability remains to be further refined.

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