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Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

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Comparison of central corneal thickness and endothelial cell measurements by Pentacam Schiempflug camera system and two noncontact specular microscopes

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Session Details

Session Title: Cornea Medical II

Session Date/Time: Tuesday 13/09/2016 | 08:00-10:30

Paper Time: 10:06

Venue: Hall C3

First Author: : I.Karaca TURKEY

Co Author(s): :    S. Guven Yilmaz   M. Palamar Onay   H. Ates              

Abstract Details


To investigate the correlation of central corneal thickness (CCT) measurements between Pentacam Schiempflug camera system and two noncontact specular microscopes, and corneal endothelial cell evaluation between two noncontact specular microscopes.


Ege University, Department of Ophthalmology, Izmir,Turkey


A total of 100 eyes of 50 healthy subjects with the mean age of 36.74±8.59 (range 22-57) years were examined by Pentacam Schiempflug Analyzer and two noncontact specular microscopes (NIDEK CEM-530, KONAN CellChek XL). Measurement differences and agreement between instruments were determined by Intraclass correlation analysis.


CCTs were correlated in between all devices, with having CellChek XL the thickest and CEM-530 the thinnest measurements (ICC=0.83; p=0.000). Mean endothelial cell density (ECD) with CEM-530 was lower than CellChek XL (2613.17±228.62 and 2862.72±170.42 cells/mm2 respectively; ICC=0.43; p=0.000). Mean coefficient of variation (CV) was 28.57±3.61 in CEM-530 and 30.30±3.53 in CellChek XL (ICC=0.23; p=0.005). Hexagonality (HEX) with CEM-530 was higher than with CellChek XL (68.70±4.16% and 45.19±6.58%, respectively (ICC=0.009; p=0.180)). The mean of the differences (CellChek XL minus CEM-530) for ECD was (249.55±142.19 cells/mm2 (95% CI 221.34–277.76); 1.71±4.36% (95% CI 0.85–2.57) in CV; and -23.51±7.42 for percentage of hexagonal cells.


Values for ECD between CellChek XL and CEM-530 correlate well, but the ECDs calculated by CellChek XL are higher than CEM-530 values. Both HEX and CV vary greatly and do not correlate sufficiently. Thus we recommend not to use CellChek XL and CEM-530 instruments interchangeably. Both CEM-530 and CellChek XL specular microscopy instruments are reliable devices for CCT measurements.

Financial Disclosure:


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