Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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CACICOL®, a new therapeutic approach to the management of persistent epithelial defects and neurotrophic keratopathy

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Session Details

Session Title: Cornea Medical II

Session Date/Time: Tuesday 13/09/2016 | 08:00-10:30

Paper Time: 08:48

Venue: Hall C3

First Author: : S.Garcia-Delpech SPAIN

Co Author(s): :    A. Herv¡s   R. Diaz Cespedes   P. Udaondo   D. Salom   A. Cisneros        

Abstract Details


Neurotrophic keratopathy (NK) is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation, possibly leading to perforation. We aimed to assess the efficacy of the so-called “ReGeneraTing Agents”(RGTA®), CACICOL®, mimicking heparan sulfates, for the management of NK and Persistent Epithelial Defects (PED).


University and Polytechnic Hospital La Fe, Valencia. Spain


We carried out an uncontrolled, prospective, single-centre clinical study on five patients (five eyes), between 48 and 65 years old, with chronic corneal NK and PED of different etiology, despite the use of hypoosmolar, preservative-free artificial tears and topical anti-inflamatory drugs, for at least 3 months. All patients were treated with CACICOL®, at a dose regimen of one daily drop every 2 days for 1 to 3 weeks. Evolution and follow-up during treatment were evaluated by slit-lamp examination, photography, fluorescein-dye testing and best corrected visual acuity.


All patients displayed complete corneal healing. Total re-epithelization occurring after a mean period of 4.6 weeks within a period of two to twelve weeks. Mean ulcer area decreased significantly, from 12.17% to 7.49% (P=0.049) in the first week, and 12.17 to 1.93% (P=0.008) at one month. At the end of the study, none of the patients displayed significant improvement in visual acuity. There were no systemic or local side effects of treatment.


CACICOL® seems to be a potentially useful, alternative, non invasive therapeutic approach in neurotrophic keratopathy and Persistent Epithelial Defects management. However, randomized studies are necessary.

Financial Disclosure:


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