Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


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Fingerprick autologous blood: a novel treatment for dry eye syndrome and persistent epithelial defects

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Session Details

Session Title: Cornea Medical II

Session Date/Time: Tuesday 13/09/2016 | 08:00-10:30

Paper Time: 08:42

Venue: Hall C3

First Author: : S.Balal UK

Co Author(s): :    A. Sharma   N. Nesaratnam   J. Than   J. Wawrzynski   B. Kumar   A. Patel     

Abstract Details


Dry eye syndrome (DES) secondary to Sjögren’s syndrome (SS) causes significant morbidity. Trials of blood-derived products (e.g. autologous serum, platelet-derived plasma) in treatment of the condition show promising results. However, their production is expensive and time-consuming. We investigate fingerprick autologous blood (FAB) as an alternative low-cost, readily accessible treatment for DES, and also for persistent epithelial defects (PED).


Moorfields eye hospital, Bedford, United Kingdom Milton Keynes General Hospital, United Kingdom Heart of England NHS Foundation Trust, United Kingdom


Patients with recalcitrant DES/PED were instructed to clean a finger, prick with a blood lancet, and apply a drop of blood to the lower fornix of the affected eye(s), 4 times daily for 8 weeks. Follow-up visits occurred 4 days, 2, 4, 8 weeks into therapy, and 4 weeks post-cessation. At each visit, visual acuity, corneal staining, Schirmer’s test, tear break-up time (TBUT), and ocular comfort index (OCI) were measured, and photographs taken. Results were analysed using Student’s paired t-test.


7 DES patients (13 eyes) were recruited. At 8 weeks, there was improvement in mean visual acuity (logMAR 0.28 to 0.18 (p=0.02)), Oxford corneal staining grade (3.46 to 2.18 (p=0.006)), and OCI score (57.86 to 32.33 (p=0.02)). Schirmer’s and TBUT improved, without statistical significance. 4 weeks post-cessation, mean acuity, staining grade and OCI worsened. 2 PED patients showed resolution after 1 month. No complications were seen.


In our small multi centre pilot study FAB appears to be a safe and effective treatment for DES secondary to SS, and PED.

Financial Disclosure:


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