Official ESCRS | European Society of Cataract & Refractive Surgeons
Copenhagen 2016 Registration Programme Exhibitor Information Virtual Exhibition Satellite Meetings Glaucoma Day 2016 Hotel Star Alliance

10 - 14 Sept. 2016, Bella Center, Copenhagen, Denmark

This Meeting has been awarded 27 CME credits


escrs app advert yo advert

Epithelial remodeling induced by a corneal hydrogel shape-changing inlay placed under a femtosecond flap

Search Title by author or title

Session Details

Session Title: Corneal Inlays for Presbyopia Correction

Session Date/Time: Sunday 11/09/2016 | 16:30-18:00

Paper Time: 17:30

Venue: Hall C1

First Author: : B.Cochener FRANCE

Co Author(s): :    A. Lang   E. Barragan Garza   A. Chayey              

Abstract Details


Demonstrate changes to the anterior stroma and epithelial thickness profiles induced by biomechanical remodeling of the anterior cornea, in the presence of the Raindrop® Near Vision Inlay


University Hospital - Brest - France


30 emmetropic subjects implanted at two clinical research sites. From cross-sectional OCT images (Optovue, Inc., Fremont, CA, USA) at 6M, the anterior and posterior surface, the inlay boundaries, and Bowman’s layer were digitized using custom MatLab (MathWorks, Inc., Natick, MA, USA) software. Biomechanical changes to the anterior stroma are reflected in Bowman’s layer (ΔBow), and epithelial changes in the epithelial thickness profile (ΔEpi). The change to the anterior corneal surface (ΔC) is related by ΔC = ΔBow + ΔEpi. ΔC was calculated from postoperative minus preoperative wavefront measurements, more accurate than OCT (5 micron/pixel). ΔBow was calculated as above


On average, 8% of the inlay volume is absorbed by the anterior stroma (flap depth of 154 ± 14 microns), with ΔBow maintaining substantially the inlay shape with a 26 micron central rise. This “Bowman volume” is redistributed by epithelial remodeling, resulting in ΔC height increase of 9 microns on average, extending to about twice the inlay diameter. On average, ΔEpi thins by 17 microns centrally, with no significant reports of SPK at or prior to the six month exam. Sub-analysis of best case profiles suggests slight peripheral epithelial thickening, just outside the inlay diameter


The anterior stroma absorbs 8% of the Raindrop Inlay’s volume. The epithelium redistributes the remaining volume, thinning by 17 microns with the final anterior corneal surface rising by 9 microns. No significant SPK was observe

Financial Disclosure:

... receives consulting fees, retainer, or contract payments from a competing company

Back to previous